The refrigerant range has become much broader with the new F-Gas regulation 517/2014 which promotes the transition to lower GWP refrigerants.


Indeed, next to energy efficiency, one of the key criteria of refrigerant choice is now the GWP. Therefore, it has been added to all new refrigerants (under applications) in the table below.


In general, refrigerants with a lower or very low GWP (except CO2) are flammable. However, there is a distinction between highly flammable refrigerants such as hydrocarbons and mildly flammable refrigerants such as HFOs or R-32.

The European Association EPEE makes available extensive information with the "F-Gas bookshelf" underr 


This table is non-exhaustive. 

 HCFCs and CFCs are banned in Europe.


R-Nummer :

Manufacturer :

Substitute :

R-Nummer Refrigerant type Substitute Composition Manufacturer Typical applications
R-454A HFO/HFC R-404A, R-407C R-32, R-1234yf
  • Opteon XL40,
  • Chemours
Medium & Low temperature (commercial and industrial refrigeration)
Not known HFO/HFC R-134a, R-407C, R-404A
  • DR-3,
  • Chemours
Mildly flammable (A2L), GWP 148, Higher capacity than Opteon YF, new stationary equipment with smaller charge size
Not known HFO/HFC R-404A
  • DR-7,
  • Chemours
Mildly flammable (A2L), GWP 246, new stationary refrigeration equipment with smaller charge size
R449A HFC R-404A, R-507, R-407A, R-407F
  • Chemours
Non flammable, GWP 1397, Retrofit
R-427A HFC R-22 R32, R125, R143a, R134
  • Arkema
R-407F HFC R-22, R-404A
  • Genetron Performax 407F,
  • Honeywell
Non flammable, GWP 1824, Commercial Refrigeration LT, MT, plug-in, vending machines
R-1233zd HCFO R-123
  • Solstice zd,
  • Honeywell
Non flammable, GWP 1, centrifugal chillers
R-448A HFC/HFO R-22, R-404A
  • Solstice N40,
  • Honeywell
Non flammable, GWP 1273, Commercial Refrigeration LT, MT, vending machines, Plug-ins
R-450A HFC/HFO R-134a
  • Solstice N13,
  • Honeywell
Non flammable, GWP 547, Heatpumps, Chillers, Vending machines, Beverage Coolers, Refrigeration


RAC Translator