The refrigerant range has become much broader with the new F-Gas regulation 517/2014 which promotes the transition to lower GWP refrigerants.


Indeed, next to energy efficiency, one of the key criteria of refrigerant choice is now the GWP. Therefore, it has been added to all new refrigerants (under applications) in the table below.


In general, refrigerants with a lower or very low GWP (except CO2) are flammable. However, there is a distinction between highly flammable refrigerants such as hydrocarbons and mildly flammable refrigerants such as HFOs or R-32.

The European Association EPEE makes available extensive information with the "F-Gas bookshelf" underr 


This table is non-exhaustive. 

 HCFCs and CFCs are banned in Europe.


R-Nummer :

Manufacturer :

Substitute :

R-Nummer Refrigerant type Substitute Composition Manufacturer Typical applications
R-404A HFC R-502, R-22 R-125, R-143a, R-134a Low temperature (commercial and industrial refrigeration)
R-507 HFC R-502, R-22 R-125, R-143a Low temperature (commercial and industrial refrigeration)
R-407C HFC R-22 R-32, R-125, R-134a a/c, chillers
R-410A HFC R-22 R-32, R-125 a/c
R-408A HCFC R-502 R-22, R-125, R-143A
  • Forane 408A, Honeywell 408A, Arcton 408A,
  • Arkema, Honeywell, Ineos
Medium and low temperature (commercial refrigeration)
R-401A HCFC R-12 R-22, R-152a, R-124 Medium temperature (vending machines, commercial refrigeration, cold rooms)
R-401B HCFC R-12, R-500 R-22, R-152a, R-124 Low temperature, transport refrigeration
R-402A HCFC R-502 R-125, R-290, R-22 Medium and low temperature (cold rooms, commercial refrigeration)
R-402B HCFC R-502 R-125, R-22, Propan Low temperature (special applications, ice machines)
R-423A HFC R-12 R-134a, R-227 Centrifugal compressors


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